The plasma membrane redox system is impaired by amyloid β-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice
DH Hyun, MR Mughal, H Yang, JH Lee, EJ Ko… - Experimental …, 2010 - Elsevier
Membrane-associated oxidative stress has been implicated in the synaptic dysfunction and
neuronal degeneration that occurs in Alzheimer's disease (AD), but the underlying
mechanisms are unknown. Enzymes of the plasma membrane redox system (PMRS)
provide electrons for energy metabolism and recycling of antioxidants. Here, we show that
activities of several PMRS enzymes are selectively decreased in plasma membranes from
the hippocampus and cerebral cortex of 3xTgAD mice, an animal model of AD. Our results …
neuronal degeneration that occurs in Alzheimer's disease (AD), but the underlying
mechanisms are unknown. Enzymes of the plasma membrane redox system (PMRS)
provide electrons for energy metabolism and recycling of antioxidants. Here, we show that
activities of several PMRS enzymes are selectively decreased in plasma membranes from
the hippocampus and cerebral cortex of 3xTgAD mice, an animal model of AD. Our results …
以上显示的是最相近的搜索结果。 查看全部搜索结果